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Study Reveals CBN's Potential in Neuroprotection

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Salk Institute researchers have discovered that CBN, a lesser-known cannabinoid with neuroprotective properties, could lead to future therapies for neurodegenerative diseases and brain injury prevention. The search for effective treatments for neurodegenerative diseases has long been a challenge, particularly as the global population ages and the prevalence of conditions like Alzheimer’s and Parkinson’s continues to rise. However, recent research from the Salk Institute offers a glimmer of hope, focusing on a lesser-known cannabinoid, cannabinol (CBN), and its potential to protect the brain against aging and neurodegeneration.

ScienceDirect
by Zhibin Liang, Ph.D., Alec M. Candib, David Soriano-Castell, Wolfgang H. Fischer, Kim D. Finley, Pamela A. Maher
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Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders

The oxytosis/ferroptosis regulated cell death pathway is an emerging field of research owing to its pathophysiological relevance to a wide range of neurological disorders, including Alzheimer's and Parkinson's diseases and traumatic brain injury.

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EurekAlert
by Pamela Maher and Zhibin Liang
From left: Pamela Maher and Zhibin Liang.

Protecting brain cells with cannabinol

Salk scientist created four Cannabis-derived CBN analogs (chemical look-a-likes) with enhanced neuroprotective properties and potential for therapeutic application in neurological disorders like Alzheimer’s, Parkinson’s, and traumatic brain injury. Their findings reveal novel aspects of CBN's neuroprotective activity and demonstrate the clinical potential of CBN and value of studying its analogs.

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